OFC Multi-ancestry GWAS Summary Statistics 

OVERVIEW
This folder contains GWAS summary statistics for orofacial clefts (OFC) in a multi-ancestry setting, including:
1) the combined multi-ancestry meta-analysis results, and
2) dataset-specific GWAS results from three contributing datasets (OFC1, OFC2, and Beaty TDT).


PHENOTYPES (5 SUBTYPES)
Results are provided for the following OFC subtypes : any, cl, clp, cp, clclcp


1) Combined multi-ancestry meta-analysis results
- OFC_multi_ancestry_<SUBTYPE>_GWAS-SSF.tsv
  Description: multi-ancestry meta-analysis summary statistics for subtype <SUBTYPE>.

  Columns:
  - chromosome: Chromosome number
  - base_pair_location: Genomic position (bp)
  - effect_allele: Effect allele
  - other_allele: Other allele
  - beta: Estimated effect size
  - standard_error: Standard error of beta
  - effect_allele_frequency: Frequency of effect_allele
  - p_value: Association p-value


2) Dataset-specific GWAS results 

- ofc1_gwas_multi_ancestry_<SUBTYPE>_GWAS-SSF.tsv
  Description: Dataset-specific GWAS summary statistics (OFC1) for subtype <SUBTYPE>.

- ofc2_gwas_multi_ancestry_<SUBTYPE>_GWAS-SSF.tsv
  Description: Dataset-specific GWAS summary statistics (OFC2) for subtype <SUBTYPE>.

- beaty_tdt_multi_ancestry_<SUBTYPE>_GWAS-SSF.tsv
  Description: Dataset-specific GWAS summary statistics from Beaty TDT (family-based) for subtype <SUBTYPE>.

  Columns:
  - chromosome: Chromosome number
  - base_pair_location: Genomic position (bp)
  - effect_allele: Effect allele
  - other_allele: Other allele
  - Est: Effect estimate 
  - n.obs: Number of observations 
  - effect_allele_frequency: Frequency of effect_allele
  - p_value: Association p-value

